Weak chemical interactions are the driving force for self-assembly in biological and supramolecular systems. The research in my group focusses on understanding these weak chemical interactions with Kohn-Sham MO theory. Our analyses of cooperativity, π assistance, and substituent effects in Watson-Crick base pairs, DNA mismatches and quadruplexes have provided groundbreaking new insights in the nature of the hydrogen bond and supramolecular aggregation. Furthermore, my group is committed to understanding the role of metal ions in self-assembly processes. The development and the implementation of chemical analysis methods to understand the nature of hydrogen bonding and chemical bonding in general are also part of my research program.
News and Information:
• Workshop 30.10-03.11.17: DNA Simulations and Repair: Computations Meet Experiments
• Conference 22.06-25.06.17: FemEx-NL 2017
• PCCP paper in top 50 of most accessed articles of 2016. Congrats to Olga!
• Well done, Stephanie! Poster prize at HRSMC symposium
• PCCP paper accepted with cover for DFT developments issue. Congrats to Francesco!