Annette G. Beck-Sickinger
Annette G. Beck-Sickinger studied chemistry and biology at University of Tübingen (Germany). After research stays with R. A. Houghten (Scripps, La Jolla), T. W. Schwartz (Copenhagen, Denmark) and E. Carafoli (ETH Zürich) she was appointed as Assistant Professor for Pharmaceutical Biochemistry at ETH Zürich. Since October 1999, she is full professor of Biochemistry and Bioorganic Chemistry at the University of Leipzig.
The group of Beck-Sickinger is interested in: structure-activity-relationships of peptides targeting G-protein coupled receptors, e. g. NPY, ghrelin, CGRP and orexin, protein expression and modification to study function and interaction.
A tight connection of chemical methods, bioorganic synthesis and molecular biology tools, including cloning, receptor mutagenesis, protein expression and cell biochemistry is applied. The technology is applied in the field of obesity research, biomaterials and tumour therapy and diagnostics
Peptide Drugs – State of the Art and Innovative Applications
Peptides have become most interesting therapeutic molecules. In the past, proteolytic cleavage and low bioavailability have been the major limitations. State-of-the art in peptide therapeutics including latest modification will be reviewed. Special focus will be given to peptides that target GPCR as well as peptides that modulate protein-protein interactions.