Chris Ulens

picture speaker

Summary

Structural principles of agonist and modulator recognition in a bacterial GABA-gated ion channel
ELIC is a bacterial pentameric ligand-gated ion channel, which is activated by GABA and allosterically modulated by benzodiazepines, with effects comparable to the human GABAA receptor. I will discuss recent insight into recognition of GABA and benzodiazepines, which we obtained from co-crystal structures of ELIC.