Daniel Obrecht

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D. Obrecht, Polyphor Ltd, Hegenheimermattweg 125, CH-4123 Allschwil


1980: Diploma in Chemistry (University of Zurich)
1980-1983: Ph.D. in Organic Chemistry (University of Zurich)
1983-1985: Postdoc at California Institute of Technology Prof. R. E. Ireland

1985-1996: F. Hoffmann-La Roche; Pharma Research
1993: Roche Lecturer
1996-ongoing: Co-founder and CSO of Polyphor Ltd
1994-ongoing: Lecturer (University of Zurich)

Scientific Publications: 63
Books: 1
Patents: 27


Medium-sized macrocyclic PEM molecules targeting challenging and therapeutically relevant GPCR’s

Protein Epitope Mimetics (PEMs) are fully synthetic, medium-sized macrocyclic peptide- like molecules designed to address challenging therapeutically relevant targets. A library of PEM molecules (PEMfinder® Library) was designed, synthesized and screened on challenging GPCRs, in particular chemokine receptors. Potent hits on CXCR4, CXCR7 and CCR10 were discovered. A CXCR4 case study which led to the discovery of POL6326 will be discussed in more detail.