Boehringer Ingelheim Pharma GmbH & Co
Herbert Nar graduated at the Technical University Munich in Chemistry and
obtained his Ph.D. from the same institute in protein crystallography. In his
postdoctoral work with Robert Huber at the Max-Planck-Institute für
Biochemie, he determined 3D structures of proteins involved in pterin
biosynthesis and studied their enzymatic mechanisms. He joined Boehringer
Ingelheim in 1995 to establish a protein crystallography laboratory. In 2000,
he took over responsibility for the Structural Research Group that comprises
units for protein expression and purification, biophysics of ligands binding,
NMR and protein crystallography. He co-chairs the Boehringer Ingelheim
fragment screening initiative.
Linking HTS-based and fragment-based approaches to a productive lead
identification process using structural biology and biophysics
The fragment-based drug discovery activities at Boehringer Ingelheim will be
Further, the organization of structural and biophysical support during hit
hit-to-lead and its project applications will be presented.