Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Dr. Jin is an Associate Professor and Director of Medicinal Chemistry in the Center for Integrative Chemical Biology and Drug Discovery at the University of North Carolina - Chapel Hill (UNC-CH). His current research interests include discovering chemical probes for protein and DNA methyltransferases and functionally selective GPCR ligands. Prior to joining UNC-CH in 2008, Dr. Jin had >10 years of drug discovery experience at GlaxoSmithKline, where he had most recently served as a Manager of Medicinal Chemistry from 2003 to 2008. Dr. Jin has published 59 peer-reviewed papers and is an inventor of 41 issued patents and patent applications.
Discovery of Chemical Probes for Methyl Writers of the Histone Code
Protein lysine methyltransferases (PKMTs) and arginine methyltransferases (PRMTs) are critical targets for manipulation to understand the histone code. However, only a limited number of PKMT and PRMT inhibitors have been reported. In this talk, the discovery of substrate-competitive, allosteric, and cofactor-competitive inhibitors of PKMTs and PRMTs will be presented.