Mike Hann

picture speaker
GlaxoSmithKline, UK

CV
Career history:
1986 present - GlaxoSmithKline, UK
o Current position: Director of Bio-Molecular Structure
o previously Director of Computational Chemistry

1981-1986 Medicinal Chemist and Computational Chemist, GD Searle, UK
1980-1981 Medicinal Chemist, Wyeth UK
1980 PhD Synthetic Organic Chemistry City University, London; Isosteric replacement studies in Enkephalins.

Special interests: Computational chemistry, Structural Biology, Lead generation and optimisation, Fragment screening, Medicinal chemistry.

Selected Publications:
Leach, A.R and Hann, M.M.. Molecular complexity and fragment-based drug discovery: ten years on. COCB 2011, 15:489496
Hann, M. M. Molecular obesity, potency and other addictions in drug discovery. MedChemComm (2011), 2(5), 349-355.
Hann, M. M.; Leach, A. R.; Burrows, J. N.; Griffen, E. Lead discovery and the concepts of complexity and lead-likeness in the evolution of drug candidates. Comprehensive Medicinal Chemistry II (2006), 4 435-458. .
Leach, AR.; Hann, MM.; Burrows, JN.; Griffen, EJ. Fragment screening: an introduction. . Molecular BioSystems (2006), 2(9), 429-446.
Hann, MM.; Oprea, TI. Pursuing the leadlikeness concept in pharmaceutical research. COCB (2004), 8(3), 255-263
Hann, MM.; Leach, AR.; Harper, G. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery. JCICS (2001), 41(3), 856-864.
Leach, A. R.; Hann, M. M.. The in silico world of virtual libraries. Drug Discovery Today (2000), 5(8), 326-336.
Bravi, G., Green, D. V. S.; Hann, M. M.; Leach, A.R . PLUMS: a Program for the Rapid Optimization of Focused Libraries. JCICS (2000), 40(6), 1441-1448.
Leach, AR.; Green, DVS Hann, MM.; Judd, DB.; Good, AC. Where are the GaPs? a rational approach to monomer acquisition and selection. JCICS (2000), 40(5), 1262-1269.
Hann, MM; Green, R. Chemoinformatics - a new name for an old problem? Current Opinion in Chemical Biology (1999), 3(4), 379-383. .
Hann MMS; Hudson B; Lewell X; Lifely R; Miller L; Ramsden N Strategic pooling of compounds for high-throughput screening. JCICS (1999), 39(5), 897-902.
Lewell X Q; Judd D B; Watson S P; Hann M M RECAP--retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry. JCICS (1998), 38(3), 511-22

Summary

Molecular Obesity, potency and other addictions in medicinal chemistry
Molecular properties are the phenotype of the molecules we choose to make. This presentation explores the profound effect molecular properties particularly lipophilicity have on attrition rates and reasons (scientific, organisational and cultural) as to why we struggle as a medchem community to always effectively control them