1986 – present - GlaxoSmithKline, UK
o Current position: Director of Bio-Molecular Structure
o previously Director of Computational Chemistry
1981-1986 – Medicinal Chemist and Computational Chemist, GD Searle, UK
1980-1981 – Medicinal Chemist, Wyeth UK
1980 PhD Synthetic Organic Chemistry – City University, London; Isosteric replacement studies in Enkephalins.
Special interests: Computational chemistry, Structural Biology, Lead generation and optimisation, Fragment screening, Medicinal chemistry.
· Leach, A.R and Hann, M.M.. Molecular complexity and fragment-based drug discovery: ten years on. COCB 2011, 15:489–496
· Hann, M. M. Molecular obesity, potency and other addictions in drug discovery. MedChemComm (2011), 2(5), 349-355.
· Hann, M. M.; Leach, A. R.; Burrows, J. N.; Griffen, E. Lead discovery and the concepts of complexity and lead-likeness in the evolution of drug candidates. Comprehensive Medicinal Chemistry II (2006), 4 435-458. .
· Leach, AR.; Hann, MM.; Burrows, JN.; Griffen, EJ. Fragment screening: an introduction. . Molecular BioSystems (2006), 2(9), 429-446.
· Hann, MM.; Oprea, TI. Pursuing the leadlikeness concept in pharmaceutical research. COCB (2004), 8(3), 255-263
· Hann, MM.; Leach, AR.; Harper, G. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery. JCICS (2001), 41(3), 856-864.
· Leach, A. R.; Hann, M. M.. The in silico world of virtual libraries. Drug Discovery Today (2000), 5(8), 326-336.
· Bravi, G., Green, D. V. S.; Hann, M. M.; Leach, A.R . PLUMS: a Program for the Rapid Optimization of Focused Libraries. JCICS (2000), 40(6), 1441-1448.
· Leach, AR.; Green, DVS Hann, MM.; Judd, DB.; Good, AC. Where are the GaPs? a rational approach to monomer acquisition and selection. JCICS (2000), 40(5), 1262-1269.
· Hann, MM; Green, R. Chemoinformatics - a new name for an old problem? Current Opinion in Chemical Biology (1999), 3(4), 379-383. .
· Hann MMS; Hudson B; Lewell X; Lifely R; Miller L; Ramsden N Strategic pooling of compounds for high-throughput screening. JCICS (1999), 39(5), 897-902.
· Lewell X Q; Judd D B; Watson S P; Hann M M RECAP--retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry. JCICS (1998), 38(3), 511-22
Molecular Obesity, potency and other addictions in medicinal chemistry
Molecular properties are the phenotype of the molecules we choose to make. This presentation explores the profound effect molecular properties – particularly lipophilicity – have on attrition rates and reasons (scientific, organisational and cultural) as to why we struggle as a medchem community to always effectively control them