# Metabolite concentration in the Teusink model of Yeast metabolism # Both in the model with original parameter values and in the model # with perturbed parameters. All metabolite concentrations are in mM # Down: 2-fold decrease in Vmax # Up: 2-fold increase in Vmax Metabolite Original Glc_0 Glc_10 Glc_20 Glc_30 Glc_40 Glc_50 Glc_60 Glc_70 Glc_80 Glc_90 Glc_100 GLT_down GLT_up HK_down HK_up PGI_down PGI_up GLYC_down GLYC_up TREH_down TREH_up PFK_down PFK_up ALD_down ALD_up G3PDH_down G3PDH_up GAPDHf_down GAPDHR_up GAPDHr_down GAPDHr_up PGK_down PGK_up PGM_down PGM_up ENO_down ENO_up PYK_down PYK_up PDC_down PDC_up SUCC_down SUCC_up ADH_down ADH_up ATPase_down ATPase_up GLCi 0.098722 7.18E-123 0.087319688 0.093939918 0.096509722 0.0978751 0.098721953 0.099298499 0.099716337 0.100033067 0.100281427 0.100481397 0.05287754 0.544913719 0.68729572 0.0326637 0.131448233 0.089506523 0.092010558 0.112603191 0.094279812 0.107715451 0.130997004 0.091094451 0.103028234 0.097134085 0.091594091 0.114845824 0.117412827 0.089127489 0.098236313 0.099637751 0.099236537 0.098466687 0.099157745 0.098517028 0.101197181 0.098274512 0.099575666 0.098471953 0.211923901 0.098636159 0.09286501 0.107481494 0.101846177 0.097092594 0.07053846 0.212653298 G6P 1.033947 -5.61E-122 0.833658799 0.950879804 0.995730374 1.019363574 1.033947094 1.043841664 1.050994864 1.056407106 1.060644902 1.064053061 0.284033879 3.221789811 0.464489485 1.170439462 1.527252733 0.819094656 1.212447588 0.82619458 1.155172498 0.870571129 1.522401824 0.859572784 1.119717779 1.000158987 1.178481543 0.877871782 1.206129701 0.977787495 1.029811573 1.041931276 1.038405634 1.031764119 1.037718182 1.032193035 1.055975168 1.030134142 1.041383062 1.031808954 1.236753291 1.033211184 1.108197176 0.956385399 1.002560428 1.05236137 1.853084555 0.667305648 F6P 0.112924 -1.76E-122 0.086286462 0.101872752 0.107841396 0.110985095 0.112924219 0.114239456 0.115190066 0.115909179 0.11647216 0.116924869 0.019265793 0.412561753 0.038895913 0.131024639 0.062258724 0.149139224 0.140649052 0.081491581 0.131228702 0.088633942 0.221290084 0.077017788 0.131063045 0.105867735 0.141553238 0.083435472 0.151085347 0.100328039 0.112019844 0.114669654 0.113898957 0.112446877 0.113748676 0.112540672 0.117740267 0.112090397 0.114549818 0.112456681 0.170888689 0.112763309 0.127275242 0.098337689 0.106962922 0.116452969 0.283088687 0.051006658 F16P 0.602148 -2.05E-33 0.490171119 0.556145121 0.581040056 0.594103153 0.602148423 0.607600914 0.611539964 0.614518867 0.616850524 0.618725202 0.142202768 15.86700296 0.265186855 0.677097875 0.445914648 0.689834354 0.666484965 0.516801474 0.650293725 0.531918869 0.447306354 0.671719097 1.008210814 0.474954809 0.730026853 0.49898889 2.153906881 0.240432082 0.57773429 0.650013629 0.62874845 0.58923246 0.624626576 0.591764995 0.737103567 0.579630469 0.646692786 0.589497075 33.674073 0.597786799 0.607258904 0.601549955 0.601022722 0.603163485 0.727170047 0.502632159 TRIO 0.777688 8.80E-29 0.700745375 0.74712496 0.763830251 0.772438318 0.777688058 0.781224034 0.783767689 0.785685349 0.787182785 0.788384486 0.360483067 4.219911842 0.508685648 0.824848391 0.665819939 0.834847246 0.820158362 0.718373353 0.809301413 0.729456268 0.666893216 0.823290182 0.757051705 0.786090971 0.876515018 0.689611713 1.603712728 0.401222294 0.757918041 0.81512168 0.79869733 0.767289398 0.795476398 0.769338889 0.879331243 0.75947106 0.812577646 0.767503785 6.666545873 0.774191378 0.78299951 0.776409656 0.776387468 0.778771926 0.892951888 0.704265894 BPG 0.000330 1.94E-32 0.000250842 0.000296754 0.000314597 0.000324063 0.000329926 0.000333914 0.000336802 0.00033899 0.000340705 0.000342086 5.515E-05 0.015388343 0.000113993 0.000385685 0.000176789 0.00044809 0.000419765 0.00023367 0.000388224 0.000255578 0.000177851 0.000421798 0.000294413 0.000345448 0.00042538 0.000224412 0.000217236 0.000462233 0.000334656 0.000321392 0.00044214 0.000274765 0.000424871 0.000285616 0.000881533 0.000233462 0.000516819 0.0002759 0.027482306 0.000311349 0.000402801 0.000261911 0.000301544 0.000347199 0.001394058 0.000129439 P3G 0.356632 -5.70E-16 0.298213744 0.332441749 0.345494604 0.352379321 0.356632472 0.359520799 0.361610432 0.363192424 0.364431727 0.365428809 0.115514866 23.12146441 0.182741532 0.39680087 0.269866251 0.409939213 0.396085131 0.307457785 0.385071141 0.31675763 0.270595645 0.398679093 0.338897505 0.364086663 0.398629527 0.30189833 0.296498716 0.414955026 0.358893788 0.352509933 0.354293859 0.357814375 0.489129419 0.295523292 1.154777562 0.224196453 0.619429121 0.282184952 91.99186157 0.330955181 0.389315046 0.322644744 0.342947977 0.36467031 0.51065471 0.288536008 P2G 0.044865 -1.08E-16 0.037116221 0.041645065 0.043380491 0.044297553 0.044864657 0.045250023 0.045528948 0.045740181 0.045905697 0.046038889 0.013741247 3.405107964 0.022147685 0.050240952 0.033083339 0.052341096 0.050414109 0.038095201 0.048813691 0.039403125 0.033179969 0.050749755 0.042413184 0.045900826 0.050771023 0.037345341 0.036632487 0.053068493 0.045179096 0.044292251 0.044539811 0.045028962 0.044589009 0.04499639 0.169579289 0.024211062 0.085884125 0.0332529 14.95107912 0.040859263 0.049449089 0.040170318 0.042964878 0.045986208 0.071345527 0.034968843 PEP 0.073670 -7.25E-16 0.059141309 0.067579822 0.070853789 0.072592165 0.073669945 0.074403529 0.07493509 0.075337978 0.07565387 0.075908197 0.019451362 9.418731862 0.032769804 0.08398889 0.048309474 0.091788651 0.087322735 0.058266438 0.082860601 0.061569609 0.048497549 0.087830808 0.068028189 0.076103251 0.088184043 0.056699711 0.05537257 0.093791041 0.074410288 0.072329333 0.072908 0.074056456 0.073023205 0.073979775 0.070199493 0.074351285 0.218208263 0.032878549 61.56604217 0.059592817 0.084826377 0.062863914 0.069214197 0.07634892 0.192959908 0.04552662 PYR 8.525448 7.37E-09 7.228029795 7.972675307 8.267891147 8.42645328 8.525447625 8.593142179 8.642357983 8.679753847 8.709131917 8.732821364 3.587542887 2766.318421 4.910848857 9.504236962 6.86817589 9.418298895 9.161441808 7.634270273 9.038950593 7.772047139 6.882924108 9.23855361 8.205448541 8.656623806 9.20463959 7.524267894 7.405420685 9.476446455 8.564974306 8.452861718 8.484354399 8.546132352 8.490594793 8.542037152 8.334786812 8.561838524 8.457704117 8.545703548 46084.2776 3.436637113 9.064718349 7.916456933 8.28593451 8.662406222 6.844115809 7.777190094 ACE 0.170125 1.16E-28 0.164282164 0.167885113 0.169122213 0.169747763 0.170125366 0.170378058 0.170559023 0.170695006 0.170800924 0.170885756 0.126924567 0.222239283 0.146126888 0.173390406 0.161600274 0.17380733 0.172878307 0.165847636 0.172232147 0.166655181 0.161690771 0.173097666 0.168687166 0.170694138 0.11202263 0.251249462 0.19370002 0.140431647 0.169098487 0.17196842 0.171175479 0.169590064 0.171017143 0.169696404 0.174852882 0.169180562 0.171847156 0.169601207 0.119856338 0.169946539 0.26325423 0.107588396 0.187664381 0.160213224 0.173493577 0.16517679 NAD 1.545561 0.000000 1.545083 1.545387 1.545484 1.545532 1.545561 1.545580 1.545594 1.545604 1.545612 1.545618 1.539392 1.552728 1.543001 1.545798 1.544719 1.545950 1.545861 1.545128 1.545770 1.545226 1.544728 1.545872 1.545417 1.545619 1.521723 1.560201 1.551681 1.535484 1.545266 1.546083 1.545859 1.545408 1.545815 1.545438 1.546881 1.545290 1.546048 1.545411 1.534538 1.545510 1.560369 1.521101 1.537158 1.549803 1.547820 1.544824 NADH 0.044439 1.59 0.044916999 0.044613475 0.044515833 0.044467657 0.044438955 0.044419904 0.044406336 0.044396183 0.044388299 0.044382 0.050607517 0.037271866 0.046999063 0.044201973 0.045281383 0.044050463 0.044138972 0.044871713 0.044229994 0.044774484 0.045272273 0.044128216 0.04458305 0.044381046 0.068276831 0.029799323 0.038318618 0.054516188 0.044733548 0.043917477 0.044140713 0.044592154 0.04418549 0.044561656 0.043119046 0.044709893 0.043951508 0.044588957 0.055462181 0.044490045 0.029630728 0.068899042 0.052842402 0.040196773 0.04218043 0.045176234 ATP 2.509318748 5.55112E-16 2.364143702 2.45576647 2.485699385 2.500499309 2.509318748 2.51517144 2.519338193 2.52245553 2.524875453 2.526808401 1.337822515 2.294093974 1.853326571 2.581687924 1.958517587 2.734187338 2.694255594 2.209788666 2.628883107 2.304140769 1.964278412 2.692367589 2.417451489 2.545164917 2.70318201 2.173596098 2.149445294 2.757810124 2.520597672 2.488373076 2.497498072 2.515232217 2.49929941 2.514063394 2.453643458 2.519706121 2.489779905 2.515109875 1.296884865 2.511302544 2.662959349 2.314260627 2.435457133 2.549960296 3.534180464 1.279041832 ADP 1.291541837 7.71808E-08 1.375648233 1.323336334 1.305673978 1.296838788 1.291541837 1.288013585 1.285495322 1.283607837 1.282140584 1.280967317 1.741746209 1.413815246 1.614091434 1.247186028 1.572980663 1.148659244 1.175107457 1.457574623 1.217417133 1.408440557 1.570600939 1.176346687 1.345536328 1.269768784 1.169234608 1.475610764 1.487389754 1.132800369 1.284733088 1.304082838 1.298635894 1.287976891 1.297557605 1.288682365 1.324578471 1.285272703 1.303244737 1.288050753 1.745694723 1.290347092 1.19551707 1.402992902 1.335161196 1.266826555 0.530046795 1.747081846 AMP 0.299139415 4.099999923 0.360208065 0.320897196 0.308626637 0.302661903 0.299139415 0.296814975 0.295166485 0.293936633 0.292983963 0.292224282 1.020431276 0.392090781 0.632581995 0.271126048 0.56850175 0.217153418 0.230636949 0.432636711 0.25369976 0.387418674 0.565120648 0.231285724 0.337012183 0.285066299 0.227583383 0.450793139 0.463164952 0.209389508 0.294669239 0.307544085 0.303866034 0.296790892 0.303142985 0.297254241 0.32177807 0.295021177 0.306975359 0.296839371 1.057420413 0.298350364 0.241523581 0.382746471 0.32938167 0.283213149 0.035772741 1.073876322