| General |
People |
Education |
Research |
Staff Molecular Toxicology
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N.P.E. Vermeulen, professor, PhD(Profile)Group Leader Phone: +31 20 5987590 Room: P2.22 Email: npe.vermeulen@few.vu.nl Website: www.isihighlycited.com (search vermeulen) |
Research is primarily focussed
on molecular mechanisms of biotransformation and bioactivation of drugs
and other xenobiotics. Interactions of these compounds with biotransformation
enzymes and other macromolecular proteins, such as Cytochromes P450,
beta-Lyases and the Estrogen receptor are studied. Relatively new lines
of research concern: on-line screening of affinities with HRS-technology,
directed evolution and (on-line) biocatalysis, and in silico research, viz. modeling
and screening of ligand/substrate-protein interactions and molecular
dynamics studies. Novel concepts and technologies find application
in the fields of drug discovery, drug development and (drug and environmental)
toxicology. |
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P.D.J. Grootenhuis, professor, PhD(Profile)Professor 'virtual screening and design' Email: P.Grootenhuis@few.vu.nl Peter_Grootenhuis@sd.vrtx.com | Dr. Peter Grootenhuis
'Extraordinary' (i.e. part-time) Professor "Virtual
Screening and Design" in the Section of Molecular
Toxicology. In Amsterdam, Grootenhuis teaches be
teaching computational drug discovery and
collaborate in research on pre-experimental
(i.e. virtual) ADME screening and modeling, with
emphasis on Cytochromes P450. In June 2006 he was
Nauta Professor at the Vrije Universiteit. Grootenhuis graduated in Chemistry at the University of Utrecht and received in 1987 his PhD-degree from Prof. D. Reinhoudt, University of Twente. He is currently Senior Director 'Discovery Chemistry' at Vertex Pharmaceuticals in San Diego, USA. He has published over 100 scientific papers and is co-inventor of 20 patents. Amongst others, he received the Gold Medal of the Royal Dutch Chemical Society. Interview with Professor P. Grootenhuis |
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J.N.M. Commandeur, PhD(Profile)Associate Professor Phone: +31 20 5987595 Room: P2.56 Email: jnm.commandeur@few.vu.nl |
Dr. Commandeur studied Pharmacochemistry at the
Vrije Universiteit, Amsterdam. He graduated in 1985
with a specialization in Molecular Toxicology. He
obtained his PhD. in 1991. Dr Commandeur's interest lies in the investigation of the enzymology and structure-activity relationships drug metabolizing enzymes, notably cytochrome P450s and cysteine conjugate beta-lyase, the characterization of the reactive intermediates formed by these enzymes, and the development of prodrugs which may act as organ-specific scavengers of these reactive intermediates. Amongst others, he is Mastercoordinator of the MSc. Drug Discovery and Safety programme and organizer of the Post-doctoral Course on Molecular Toxicology (yearly), the LACDR/EUFEPS course on High-Throughput Drug Metabolism and Disposition (yearly) and the ULLA Drug Metabolism course (bi-annually). He is member of the editorial board of Toxicology Letters and a referee of several journals. |
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C. Oostenbrink, PhD(Profile)Assistant Professor Phone: +31 20 5987606 Room: P2.62 Email: c.oostenbrink@few.vu.nl Website: www.few.vu.nl/~oostnbrk |
Chris Oostenbrink studied both Chemistry and
Pharmacochemistry at the Vrije Universiteit,
Amsterdam. He graduated twice in 2000 with
specialisations in Theoretical Chemistry and
Computational Medicinal Chemistry, in both cases cum
laude. In 2004 he obtained his PhD. at the Swiss
Federal Institute of Technology (ETH) in Zurich,
Switzerland, in the group of prof. W.F. van
Gunsteren on the calculation of (binding) free
energies in biomolecular simulations. In October 2004, he was appointed Assistent professor Computational Medicinal Chemistry and Toxicology (CMCT) at the VU. Since 2005 he received several 'young talent' grants, two Bioinformatics Breakthrough grant from NWO-Horizon, and a VENI-grant from NWO-CW. In his work he is aiming to inter-connect computational and experimental approaches to study biomolecular systems and to show that computational tools studying protein structure and dynamics and protein-ligand interactions are complementary to experiments. |
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J.C. Vos, PhD(Profile)Assistant Professor Phone: +31 20 5987569 Room: KA 283a Email: jc.vos@few.vu.nl |
Dr. ir. J.C. Vos studied molecular sciences at the Agricultural University of Wageningen. He received his PhD in 1993 at the University of Amsterdam for his work carried out at the European Molecular Biology Laboratory at Heidelberg (Germany) on vaccinia virus gene regulation. He spend two post-doctoral terms at the Dutch Cancer Institute in Amsterdam studying (i) DNA transposition in Caenorhabditis elegans (ii) the structure of the human Transporter Associated with Antigen Processing. In 2000 he moved to the section of Biochemistry and Molecular Biology of the Vrije Universiteit focusing on the macromolecular interactions involved in the biogenesis of ribosomes in Saccharomyces cerevisiae. Since 2006, as member of the section of MolTox, stress-response in yeast related to P450 biotransformation will be studied. |
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J.E. van Muijlwijk-Koezen, PhDAssistant Professor Phone: +31 20 5987611 Room: P2.64 Email: je.van.muijlwijk@few.vu.nl |
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| PhD Students and Postdocs |
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S.B.A. de Beer, Msc PhD student Phone: +31 20 5987608 Room: P2.75bbr> Email: sbr210@few.vu.nl |
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B. E. de Brito Palma PhD student Phone: +31 20 5987593 Room: P2.40 Email: bbritopalma.gene@fcm.unl.pt |
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M. Damstén, MSc PhD student Phone: +31 20 5987591 Room: P2.47b Email: damsten@few.vu.nl |
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S. Dragovic, MSc PhD student Phone: +31 20 5987593 Room: P2.40 Email: sdragov@few.vu.nl |
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J. Hritz, PhD postdoc Phone: +31 20 5987608 Room: P2.75a Email: hritz@few.vu.nl Website: www.few.vu.nl/~hritz |
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J.S. van Leeuwen, MSc PhD student Phone: +31 20 5987593 Room: P2.40 Email: J.van.Leeuwen@few.vu.nl |
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P. Vasanthanathan, MSc PhD student Phone: +31 20 5987612 Room: P2.75b Email: nobelvasanth@gmail.com |
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J. Reinen, MSc PhD student Phone: +31 20 5987593 Room: P2.40 Email: reinen@few.vu.nl |
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V. Rea, MSc PhD student Phone: +31 20 5987593 Room: P2.40 Email: vrea@few.vu.nl |
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E. Stjernschantz, MSc PhD student Phone: +31 20 5987612 Room: P2.75b Email: eva@few.vu.nl |
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E. Vottero, PhD postdoc Phone: +31 20 5987593 Room: P2.40 Email: evottero@few.vu.nl |
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G. Vredenburg, MSc PhD student Phone: +31 20 5987593 Room: P2.40 Email: g.vredenburg@few.vu.nl |
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| Technicians |
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E.J. Groot Technician Phone: +31 20 5987592 Room: P2.47a Email: groot@few.vu.nl |
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J. Lastdrager Technician Phone: +31 20 5987592 Room: P2.47a Email: jlastdr@few.vu.nl |
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| Recent staff |
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J. Kool, PhD PhD student Vrije Universiteit Faculteit der Exacte Wetenschappen An.Ch.& Ap.Spect Phone: +31 20 59 87542 Room: O-348A Email: J.Kool@few.vu.nl |
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B.M.A. van Vugt, PhD PhD student Technical University Delft BT/Enzymology group Julianalaan 67 2628 BC Delft,The Netherlands Email: b.m.a.vanvugt-lussenburg@tudelft.nl Website: www.few.vu.nl/~lussnbrg |
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C. de Graaf, PhD PhD student Universite Louis Pasteur Strasbourg, France Email: Chris.De-graaf@pharma.u-strasbg.fr |
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P.H.J. Keizers, PhD PhD student Leiden University Metalloprotein group Gorlaeus Laboratoria Einsteinweg 55 2333 CC Leiden, The Netherlands Phone: +31 (0)71 527 43 55 Email: p.keizers@chem.leidenuniv.nl |
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M. Rooseboom, PhD PhD student Address:N.V. Organon Department of Pharmacology Postbus 20 15340 BH Oss, The Netherlands Phone: +31 412 665737 Email: martijn.rooseboom@organon.com |
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K.A. Feenstra, PhD postdoc Phone: +31 20 5987608 Room: P2.75a Email: feenstra@few.vu.nl Website: www.chem.vu.nl/~feenstra |
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Hilmi Orhan, PhD postdoc (STW-NWO) Address:Hacettepe University Faculty of Pharmacy Toxicology Department 06100 Ankara, Turkey Phone: +90 312 30 92 958 Email: hilmi@tr.net |
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Hande Gurer-Orhan, Dr. postdoc (EU) Address:Hacettepe University Faculty of Pharmacy Toxicology Department 06100 Ankara, Turkey Phone: +90 312 30 92 958 Email: handegurer@yahoo.com |
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D. Acohen, MSc PhD student www.daanacohen.nl |
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J. Venhorst, PhD PhD student Address:Solvay Pharmaceuticals Postbus 900 1380 DA Weesp, The Netherlands Phone: +31 294 477837 Email: Jennifer.Mccormack@solvay.com |
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E. Vriese, MSc researcher (project based) Phone: +31 20 5987606 Room: P2.62 Email: vriese@few.vu.nl |
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I. Sandelowsky, professor Sabbatical Professor Address:Institute for Biological Research Ness Ziona Israel Email: sandelowsky2004@yahoo.com |
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J. Starikow, PhD postdoc (EU) Address:Spandauerdam 137 14050 Berlin, Germany Phone: +49 30 83856760 Email: starikow@chemie.fu-berlin.de |
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S. van Liempd, PhD PhD student J&J pharmaceuticals |
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R. Appiah-Opong, PhD PhD student Noguchi Memorial Institute for Medical Research, Ghana |